Human IL10 Protein, Recombinant
產(chǎn)品貨號：PR00189HuM1
$ 詢價
規(guī)格 100ug
產(chǎn)品名稱：Human IL10 Protein, Recombinant
純度：≥95 % as determined by SDS-PAGE
內(nèi)毒素：< 1.0 EU per μg of the protein as determined by the LAL method
生物活性：/
序列起止：Ser19~Asn178
標簽：N-His tag
Uniprot鏈接：P22301
表達系統(tǒng)：293F
種屬：Human
預(yù)測 N 端：Met
預(yù)測分子量：17.6
緩沖液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
運輸方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
穩(wěn)定性 & 儲存條件：Store for up to one year at -20°C to -80°C as lyophilized powder.
復(fù)溶：Please refer to COA for detailed information
質(zhì)量驗證圖：/
別稱：CSIF IL-10
背景信息：The human IL10 gene is 4.7 kb in size and is located on the long arm of chromosome 1. It contains five exons. Biologically functional IL-10 exists in the form of a 36 kDa homodimer composed of two non-covalently bonded mono-mers each with 160 amino acids length. IL-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-B activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
全稱：Interleukin-10 (IL10)
說明書：待上傳