Human TGFBR2 Protein, Recombinant
產(chǎn)品貨號：PR00424HuP1
$ 詢價
規(guī)格：100ug
產(chǎn)品名稱：Human TGFBR2 Protein, Recombinant
純度：≥95 % as determined by SDS-PAGE
內(nèi)毒素：/
生物活性：/
序列起止：Thr23~Gln166
標(biāo)簽：C-His tag
Uniprot鏈接：P37173
表達(dá)系統(tǒng)：E.coli
種屬：Human
預(yù)測 N 端：Met
預(yù)測分子量：15.84 kDa
緩沖液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
運輸方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
穩(wěn)定性 & 儲存條件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
復(fù)溶：Please refer to COA for detailed information
別稱：MFS2
背景信息：TGF-beta RII. Most cell types express three sizes of receptors for TGF-beta. These are designated Type I (53 kDa), Type II (70-85 kDa), and Type III (250-350 kDa). The Type III receptor, a proteoglycan that exists in membrane-bound and soluble forms, binds TGF-beta 1, TGF-beta 2, and TGF-beta 3 but does not appear to be involved in signal transduction. The Type II receptor is a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I receptor is also a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta. Current evidence suggests that signal transduction requires the cytoplasmic domains of both the Type I and Type II receptors.The recombinant soluble TGF-beta Type II receptor is capable of binding TGF-beta 1, TGF-beta 3, and TGF-beta 5 with sufficient affinity to act as an inhibitor of these isoforms at high concentrations. The soluble receptor also binds TGF-beta 2, but with an affinity at least two orders of magnitude lower. Binding of TGF-beta 1, TGF-beta 3, and TGF-beta 5 to the soluble TGF-beta Type II receptor can also be demonstrated by using the soluble receptor as a capture agent on ELISA plates and this observation has been used as the basis for the development of immunoassays for these isoforms of TGF-beta.
全稱：TGF-beta receptor type-2 (TGFBR2)
說明書：待上傳