Human KIR2DS4 Protein, Recombinant
產(chǎn)品貨號：PR00507HuM1
$ 詢價
規(guī)格 100ug
產(chǎn)品名稱：Human KIR2DS4 Protein, Recombinant
純度：≥95 % as determined by SDS-PAGE
內(nèi)毒素：< 1.0 EU per μg of the protein as determined by the LAL method
生物活性：/
序列起止：Gln22~His245
標(biāo)簽：N-His tag
Uniprot鏈接：P43632
表達(dá)系統(tǒng)：CHOS
種屬：Human
預(yù)測 N 端：Met
預(yù)測分子量：/
緩沖液：20mM Tris, 250mM imidazole, 500mM NaCl, pH8.0, containing 10% glycerol.
運(yùn)輸方式：This Protein is shipped as lyophilized powder at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
穩(wěn)定性 & 儲存條件：Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
復(fù)溶：Please refer to COA for detailed information
質(zhì)量驗(yàn)證圖：/
別稱：CD158I, KIR1D, KIR412, KKA3, NKAT8, PAX, Cl-39, Natural killer-associated transcript 8, CD158 antigen-like family member I, NK receptor CL-39/CL-17
背景信息：KIR2DS4/CD158i. KIR2DS4 (2DS4), previously called NKAT-8 and designated CD158i, is a type I transmembrane glycoprotein that belongs to the killer cell Ig-like receptor (KIR) family (1). KIRs are expressed on CD56dim NK cells and T cell subsets where they differentiate normal from abnormal cells and regulate effector functions in the innate immune system (1-3). KIRs are named for the number of Ig-like domains (2D or 3D) in the extracellular domain (ECD), and whether they have long or short (L, S) cytoplasmic tails. KIR2DS4 cDNA encodes 304 amino acids (aa) including a 21 aa signal sequence, a 224 aa ECD, a 20 aa transmembrane sequence and a 39 aa cytoplasmic domain. KIR receptors have no structural orthologs in nonprimates, although mouse Ly-49 proteins perform similar functions (2). Like other activating KIRs, KIR2DS4 has a short tail and a positively charged amino acid (aa) within the transmembrane domain that interacts with the ITAM-bearing signaling adaptor, DAP12 (2, 3). Expression of activating KIR is balanced with inhibitory KIR to impart specificity to the immune response. KIR2DS4 recognizes six HLA-C allotypes and two HLA-A allotypes (A*1101 and A*1102) but no HLA-B allotypes (4, 5). It has also been suggested that KIR2DS4 recognizes a non-MHC ligand, based on specific binding to melanoma cells that lack MHC Class I (6). A common allele, KIR2DS4*003, is present in up to 89% of Caucasians and ~30% of Asians; it creates a prematurely terminated, soluble, inactive form (7, 8). Lack of functional KIR2DS4 can potentially create unbalanced inhibition of killer cell function (4, 8).
全稱：Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)
說明書：待上傳