Anti-Phospho-SAPK/JNK (Thr183/Tyr185) Antibody, Recombinant Antibody
產(chǎn)品編號(hào)：RPTMB6A1
￥ 詢(xún)價(jià)
規(guī)格 100ug
產(chǎn)品名稱(chēng)：Anti-Phospho-SAPK/JNK (Thr183/Tyr185) Antibody, Recombinant Antibody
克隆號(hào)：/
抗體亞型：/
經(jīng)驗(yàn)證的應(yīng)用：WB/IP/IHC
交叉反應(yīng)：Human, Mouse, Rat, Fruitfly, Yeast
特異性：Recognizes Phospho-SAPK/JNK (Thr183/Tyr185)
免疫原：Synthetic peptide
制備方法：/
來(lái)源：Recombinant Rabbit IgG
純化：Protein A purified
緩沖液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
偶聯(lián)物：Unconjugated
狀態(tài)：Liquid
運(yùn)輸方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
儲(chǔ)存條件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
別稱(chēng)：/
背景信息：The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists. As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase . Stress signals are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42). Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs. Alternatively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germinal center kinase (GCK) family member. There are three SAPK/JNK genes each of which undergoes alternative splicing, resulting in numerous isoforms. SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors.
全稱(chēng)：/
說(shuō)明書(shū)：待上傳